Catalog Number: 1366
Chemical Name: 1-(2-Naphthalenyl)-2-propen-1-one
Biological Activity
Potent, selective inhibitor of Janus tyrosine kinase 3 (JAK3) which binds competitively to the JAK3 ATP site. pIC50 values are 6.8, 5.0, 4.7, and < 5.0 for JAK3, EGFR, JAK1 and CDK4 respectively. Inhibits STAT-5 phosphorylation and T cell proliferation.
Technical Data
  • M.Wt:
  • Formula:
  • Purity:
  • Storage:
    Desiccate at -20°C
  • CAS No:
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis. All Tocris products are intended for laboratory research use only.
Additional Information
Licensing Caveats:
Sold with the permission of AstraZeneca Ltd.
Background References
  1. IL-2 induces a WAVE2-dependent pathway for actin reorganization that enables WASp-independent human NK cell function.
    Orange et al.
    J.Clin.Invest., 2011;121:1535
  2. Naphthyl ketones: a new class of janus kinase 3 inhibitors
    Brown et al.
    Bioorg.Med.Chem.Lett., 2000;10:575

The citations listed below are publications that use Tocris products. Selected citations for ZM 449829 include:

Showing Results 1 - 2 of 2

  1. Upregulation of Nicotinic Acetylcholine Receptor α4+β2 through a Ligand-Independent PI3Kβ Mechanism That Is Enhanced by TNFα and the Jak2/p38Mapk Pathways.
    Authors: Rogers and Gahring
    PLoS One
  2. A profiling platform for the characterization of transglutaminase 2 (TG2) inhibitors.
    Authors: Schaertl Et al.
    J Biomol Screen
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