Chemical Name: 1-(2-Naphthalenyl)-2-propen-1-one
Biological ActivityZM 449829 is a potent, selective inhibitor of Janus tyrosine kinase 3 (JAK3) which binds competitively to the JAK3 ATP site. pIC50 values are 6.8, 5.0, 4.7, and < 5.0 for JAK3, EGFR, JAK1 and CDK4 respectively. Inhibits STAT-5 phosphorylation and T cell proliferation.
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Tocris products are intended for laboratory research use only, unless stated otherwise.
IL-2 induces a WAVE2-dependent pathway for actin reorganization that enables WASp-independent human NK cell function.
Orange et al.
Naphthyl ketones: a new class of janus kinase 3 inhibitors
Brown et al.
Citations for ZM 449829
The citations listed below are publications that use Tocris products. Selected citations for ZM 449829 include:
4 Citations: Showing 1 - 4
Upregulation of Nicotinic Acetylcholine Receptor α4+β2 through a Ligand-Independent PI3Kβ Mechanism That Is Enhanced by TNFα and the Jak2/p38Mapk Pathways.
Authors: Rogers and Gahring
PLoS One 2015;10:e0143319
A profiling platform for the characterization of transglutaminase 2 (TG2) inhibitors.
Authors: Schaertl Et al.
J Biomol Screen 2010;15:478
JAK/STAT and PI3K/AKT pathways form a mutual transactivation loop and afford resistance to oxidative stress-induced apoptosis in cardiomyocytes.
Authors: Lu Et al.
Cell Physiol Biochem 2008;21:305
The JAK/STAT pathway is essential for opioid-induced cardioprotection: JAK2 as a mediator of STAT3, Akt, and GSK-3 beta.
Authors: Gross Et al.
Am J Physiol Heart Circ Physiol 2006;291:H827
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