Potent, selective inhibitor of Janus tyrosine kinase 3 (JAK3) which binds competitively to the JAK3 ATP site. pIC50
values are 6.8, 5.0, 4.7, and < 5.0 for JAK3, EGFR, JAK1 and CDK4 respectively. Inhibits STAT-5 phosphorylation and T cell proliferation.
Desiccate at -20°C
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IL-2 induces a WAVE2-dependent pathway for actin reorganization that enables WASp-independent human NK cell function.
Orange et al.
Naphthyl ketones: a new class of janus kinase 3 inhibitors
Brown et al.
The citations listed below are publications that use Tocris products. Selected citations for ZM 449829 include:
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