ZMPSTE24 Antibody

Novus Biologicals | Catalog # NBP3-12432

Novus Biologicals
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Key Product Details

Species Reactivity

Human, Mouse, Rat

Applications

Western Blot, ELISA, Immunoprecipitation

Label

Unconjugated

Antibody Source

Polyclonal Rabbit
View all ZMPSTE24 Primary Antibodies »

Product Specifications

Immunogen

Synthetic peptide taken within amino acid region 215-245 on human ZMPSTE24 protein.

Clonality

Polyclonal

Host

Rabbit

Scientific Data Images for ZMPSTE24 Antibody

Western Blot: ZMPSTE24 Antibody [NBP3-12432]

Western Blot: ZMPSTE24 Antibody [NBP3-12432]

Western Blot: ZMPSTE24 Antibody [NBP3-12432] - SKNBE cells (1) and Zmpste24 (B). 1:500 antibody dilution in DiluObuffer. Apparent MW is 62 KDa.

Applications for ZMPSTE24 Antibody

Application
Recommended Usage

ELISA

1:10000

Immunoprecipitation

1:200

Western Blot

1:500

Formulation, Preparation, and Storage

Purification

Affinity purified

Formulation

Contains Tris, HCl/glycine buffer (pH 7.4-7.8), 30% glycerol, 0.5% BSA, along with cryo-protective agents, and HEPES (exact storage and stabilization buffer information is proprietary).

Preservative

0.02% Sodium Azide

Concentration

Please see the vial label for concentration. If unlisted please contact technical services.

Shipping

The product is shipped with polar packs. Upon receipt, store it immediately at the temperature recommended below.

Stability & Storage

Store at 4C short term. Store at -20C long term. Avoid freeze-thaw cycles.

Background: ZMPSTE24

ZMPSTE24, also known as FACE1, is a zinc metalloprotease involved in the post-translational processing of Lamin A/C precursors. Specifically, ZMPSTE-24 proteolytically removes the C-terminal three residues of the farnesylated Lamin proteins.

FACE-1 is widely expressed, with the highest levels found in the kidney, prostate, testis and ovary.

Mutations in ZMPSTE24 have been associated with human diseases such as mandibuloacral dysplasia with type B lipodystrophy (MADB) and lethal tight skin contracture syndrome (LTSCS), often due to the accumulation of LMNA precursors. It is theorized that ZMPSTE24 may play an important role in human ageing, based on its association with LMNA.

Alternate Names

zona pellucida binding protein 2, zona pellucida-binding protein 2, ZPBP-like protein, ZPBPLMGC41930

Gene Symbol

ZMPSTE24

Additional ZMPSTE24 Products

Product Documents for ZMPSTE24 Antibody

Certificate of Analysis

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Product Specific Notices for ZMPSTE24 Antibody

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

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