Catalog Number: 6001
Chemical Name: 2-(Hexylthio)-6-hydroxy-4(3H)-pyrimidinone
Biological Activity
Selective medium-chain free fatty acid receptor GPR84 agonist (EC50 = 139 nM). Exhibits no response at GPR40, GPR41, GPR119 or GPR120 at 100 uM. Activates calcium mobilization, inhibits cAMP accumulation, and induces ERK1/2 phosphorylation, receptor desensitization and internalization in vitro.
Technical Data
  • M.Wt:
    228.31
  • Formula:
    C10H16N2O2S
  • Solubility:
    Soluble to 50 mM in DMSO and to 100 mM in ethanol
  • Purity:
    >98%
  • Storage:
    Store at -20°C
  • CAS No:
    376616-73-8
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis. All Tocris products are intended for laboratory research use only.
Background References
  1. Design and synthesis of 2-alkylpyrimidine-4,6-diol and 6-alkylpyridine-2,4-diol as potent GPR84 agonists.
    Liu et al.
    ACS Med.Chem.Lett., 2016;7:579
  2. Discovery and characterization of a novel small-molecule agonist for medium-chain free fatty acid receptor G protein-coupled receptor 84.
    Zhang et al.
    J.Pharmacol.Exp.Ther., 2016;357:337
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