ZQ 16
Discontinued Product
Chemical Name: 2-(Hexylthio)-6-hydroxy-4(3H)-pyrimidinone
Purity: ≥98%
Biological Activity
ZQ 16 is a selective medium-chain free fatty acid receptor GPR84 agonist (EC50 = 139 nM). Exhibits no response at GPR40, GPR41, GPR119 or GPR120 at 100 μM. Activates calcium mobilization, inhibits cAMP accumulation, and induces ERK1/2 phosphorylation, receptor desensitization and internalization in vitro.Technical Data
The technical data provided above is for guidance only.
For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
Background References
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Design and synthesis of 2-alkylpyrimidine-4,6-diol and 6-alkylpyridine-2,4-diol as potent GPR84 agonists.
Liu et al.
ACS Med.Chem.Lett., 2016;7:579 -
Discovery and characterization of a novel small-molecule agonist for medium-chain free fatty acid receptor G protein-coupled receptor 84.
Zhang et al.
J.Pharmacol.Exp.Ther., 2016;357:337
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Citation for ZQ 16
The citations listed below are publications that use Tocris products. Selected citations for ZQ 16 include:
1 Citation: Showing 1 - 1
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Similarities and differences between the responses induced in human phagocytes through activation of the medium chain fatty acid receptor GPR84 and the short chain fatty acid receptor FFA2R.
Authors: Sundqvist
Biochim Biophys Acta 2018;1865(5):695
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