TGF-beta Superfamily Phylogenetic Tree

The mature domains of each molecule were aligned using ClustalX [1]. The alignment was then processed with Protdist and Neighbor using the Dayhoff PAM Matrix [2]. The tree used as the basis for the dendrogram was created using TreeView [3]. The branches of the phylogenetic tree represent divergence of each branch member from a common ancestor. The branch lengths reflect the number of amino acid changes between each protein and that hypothetical ancestor, and imply how much time has passed since the divergence.

1. Chenna, R. et al. (2003) Nucleic Acids Res. 31:3497.
2. Felsenstein, J. (1989) Cladistics 5:164.
3. Page, R. D. M. (1996) Computer Applications in the Biosciences 12:357.