3 results for "ACE-2" in Products
ACE-2 Products
Angiotensin converting enzyme 2 (ACE-2), also known as ACEH (ACE homolog), is an integral membrane protein and a zinc metalloprotease of the ACE family. The predicted human ACE-2 protein sequence consists of 805 amino acids, including a N-terminal signal peptide, a single catalytic domain, a C-terminal membrane anchor, and a short cytoplasmic tail. ACE-2 cleaves angiotensins I and II as a carboxypeptidase.
ACE-2 also serves as the receptor for the SARS-CoV and SARS-CoV-2 viruses. Binding of the S1 domain of the SARS Coronavirus Spike protein to ACE-2 initiates viral entry into the host cell. Recently, this interaction between SARS-CoV-2 and ACE-2 has become an area of intense therapeutic interest to develop treatments against COVID-19.
Potent and selective angiotensin-converting enzyme 2 (ACE2) inhibitor
| Chemical Name: | N-[(1S)-1-Carboxy-3-methylbutyl]-3-[(3,5-dichlorophenyl)methyl]-L-histidine |
| Purity: | ≥98% |
HIF-PH inhibitor; erythropoietic
| Alternate Names: | FG 4592 |
| Chemical Name: | N-[(4-Hydroxy-1-methyl-7-phenoxy-3-isoquinolinyl)carbonyl]glycine |
| Purity: | ≥98% |
Pan-histone deacetylase inhibitor
| Chemical Name: | (2E)-N-Hydroxy-3-[4-[[[2-(2-methyl-1H-indol-3-yl)ethyl]amino]methyl]phenyl]-2-propenamide |
| Purity: | ≥98% |
