2 results for "Adenosine A1 Receptor Modulators" in Products
Adenosine A1 Receptor Modulators
The A1 receptor is a member of the adenosine receptor group of G-protein-coupled receptors that also includes A2A, A2B and A3. A1 receptors display high expression levels in the brain (cortex, cerebellum, hippocampus), dorsal horn of the spinal cord, eye, adrenal gland and atria. Lower expression levels are also found in the liver, kidney, skeletal muscle, adipose tissue, colon, testes, salivary glands and oesophagus. A1 receptors play a role in lipolysis, antinociception and cardio- and neuroprotection. The human A1 receptor gene is localized on chromosome 1 (1q32.1)
Positive allosteric modulator of A1 receptors
| Chemical Name: | (2-Amino-4,5-dimethyl-3-thienyl)-[3-(trifluoromethyl)phenyl]methanone |
| Purity: | ≥98% |
Positive allosteric modulator (PAM) of A1 receptors; also allosteric partial agonist in absence of orthosteric agonist
| Chemical Name: | [2-Amino-4-[3-(trifluoromethyl)phenyl]-3-thienyl]phenylmethanone |
| Purity: | ≥98% |
