AIP/ARA9 Proteins and Enzymes

Aryl-hydrocarbon receptor-interacting protein immunophilin homolog ARA9, also known as AIP and XAP-2, is known to affect the potency and efficacy of AHR agonists and have functional consequences on AHR signal transduction. ARA9 may also play a positive role in AHR-mediated signaling, by influencing its ligand receptivity and/or nuclear targeting ability. Defects in AIP can lead to familial isolated pituitary adenoma (FIPA), growth hormone-secreting pituitary adenoma (GHSPA), ACTH-secreting pituitary adenoma (ASPA), and prolactin-secreting pituitary adenoma (PSPA).