APE1 Redox Products

E3330 is a specific chemical inhibitor of the APE1 protein redox domain. Therefore, E3330 inhibits APE-1 redox regulation of transcription factors, but does not affect Ape1 DNA repair activity. APE1 is a dual functioning protein invloved in DNA repair and redox regulation of transcription factors. The APE1 DNA repair function primarily involves apurinic/apyrimidinic endonuclease DNA base excision repair activity and proofreading exonuclease activity. The protein also modulates DNA binding ...