B8R Proteins and Enzymes

B8R is a secreted Interferon gamma binding protein encoded by the open reading frame of the Vaccina virus (smallpox). B8R binds IFN--gamma orthologs from multiple species including human, rat, rabbit, bovine, and chicken with high affinity, but it binds mouse IFN-gamma with low affinity. During infection, virally-induced B8R binds and sequesters en...