BMP-5 Proteins and Enzymes

Bone Morphogenetic Protein-5 (BMP-5) is a TGF-beta superfamily homodimeric cytokine. Cellular responses to BMP-5 are mediated by the formation of hetero-oligomeric complexes of type I and type II serine/threonine kinase receptors. BMP-5 is expressed by chondrocytes in proliferating and hypertrophic zones of bone growth plates. It contributes to limb development by promoting proliferation and differentiation of chondrocytes as well as apoptosis of undifferentiated mesoderm. Genetic defects in ...