CLEC4E Proteins and Enzymes

CLEC4E, also known as Mincle, is a transmembrane C-type lectin that functions as an activating innate immune receptor on monocytes, macrophages, and immature dendritic cells. Human CLEC4E binds to mycobacterial glycolipids including the immune adjuvant TDM (cord factor), its synthetic analog TDB, and GroMM. It also binds the nuclear protein SAP130 ...