Cochlin Proteins and Enzymes

Cochlin is the major protein component of inner ear extracellular matrix. It contains one LCCL/FCH and two VWF-A domains, any of which may be deleted by alternate splicing. Cochlin is a target of IFN- producing T cells in autoimmune sensorineural hearing loss (ASNHL). Cochlin is upregulated in glaucoma and promotes the aggregation of trabecular me...