Corneodesmosin Proteins and Enzymes

Corneodesmosin (CDSN) is a highly polymorphic glycoprotein that is secreted by differentiated keratinocytes and by inner root sheath cells of hair follicles. Corneodesmosin forms oligomers and associates homophilically to strengthen the adhesion between corneocytes. Sequential proteolysis of Corneodesmosin diminishes its ability to mediate adhesion, and this is a prerequisite for normal desquamation of the skin. Defects in the synthesis or proteolysis of Corneodesmosin are associated with the development of psoriasis and hypotrichosis of the scalp.