Endophilin B1/Bif-1 Proteins and Enzymes

Endophilin B1/Bax-interacting Factor 1 (Bif-1), also known as SH3-domain GRB2-like Endophilin B1 (SH3GLB1), is a 365 amino acid (aa) member of the endophilin protein family with a predicted molecular weight of approximately 43 kDa. The human protein shares 96% and 95% aa sequence identity with the mouse and rat orthologs, respectively. Endophilin B1/Bif-1 contains an N-terminal N-BAR domain and a C-terminal SH3 domain that are important for its roles in apoptosis and autophagy. The N-BAR domain ...