GPR64 Proteins and Enzymes

GPR64 is an Orphan-B GPCR with an unknown ligand. HE6 is endogenously cleaved into two pieces at the GPCR proteolytic site (GPS) located adjacent to the first transmembrane helix as a mechanism to compartmentalize the cell adhesion and GPCR activation functions. GPR64 has been reported in the epididymis. ESTs have been isolated from embryo, kidney, placenta, skeletal muscle, and testis libraries.