Hematopoietic Prostaglandin D Synthase/HPGDS Proteins and Enzymes

Prostaglandin D Synthase (PGDS) catalyzes the conversion of prostaglandin (PG) H2 to PGD2, which is a major prostanoid produced in a variety of tissues. Two types of PGDS have been isolated: the glutathione-dependent hematopoietic PGDS (HPGDS) and the glutathione-independent lipocalin type PGDS. HPGDS is a cytosolic enzyme that is expressed in mast cells and antigen presenting cells. It is the only mammalian member of the class Sigma glutathione S transferase, showing a broad specificity ...