HNF-6/ONECUT1 Proteins and Enzymes

HNF-6 (also ONECUT1; one cut domain family member 1; OC-1) is a monomeric 53-56 kDa member of the One Cut-domain containing class of homeodomain proteins. It is expressed in embryonic hepatic and pancreatic islet anlage, plus adult hepatocytes and intestinal epithelial cells. HNF-6 is a transcriptional activator that is known to interact with Foxa2. Genes regulated by HNF-6 include Glut2, alpha1AT, alpha-fetoprotein and HNF-3 beta. Human HNF-6 is 465 amino acids (aa) in length. It contains two ...