IRF8 Proteins and Enzymes

IRF8 (interferon regulatory factor 8; also ICSBP) is a 50 kDa member of the IRF family of proteins. It is expressed in myeloid, dendritic and B cells and interacts with PU.1 to regulate the expression of TLR4, IL-18, IL-12p35, and PTPN13, a Fas-associated phosphatase that blocks Fas-induced apoptosis. Human IRF8 is 426 amino acids (aa) in length. It contains an N-terminal DNA-binding basic region (aa 9 - 110) and at least one regulatory phosphorylation site at Tyr95. Over aa 255 - 426, human IRF8 shares 90% and 88% aa identity with canine and mouse IRF8, respectively.