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2 results for "Isocitrate dehydrogenase 1 Inhibitors" in Products
Isocitrate dehydrogenase 1 Inhibitors
Isocitrate dehydrogenase 1 (IDH1) EC:1.1.1.42 is one of three isocitrate dehydrogenase isoforms found in humans. IDH1 and IDH2 are homodimeric enzymes found in the cytoplasm and mitochondria, respectively. In their wildtype form, they catalyze the conversion of isocitrate to α-ketoglutarate (α-KG), an essential intermediate in the Krebs cycle. IDH1 and IDH2 are structurally and functionally similar, but they differ substantially from IDH3 (an enzyme that plays a role in the Krebs ...
Potent and selective inhibitor of mutant isocitrate dehydrogenase 1 (mIDH1)
| Chemical Name: | N-[2-(Cyclohexylamino)-1-(2-methylphenyl)-2-oxoethyl]-N-(3-fluorophenyl)-2-methyl-1H-Imidazole-1-acetamide |
| Purity: | ≥98% |
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Potent inhibitor of mutant isocitrate dehydrogenase (mIDH1)
| Chemical Name: | (2S)-N-{(1S)-1-(2-Chlorophenyl)-2-[(3,3-difluorocyclobutyl)amino]-2-oxoethyl}-1(4-cyanopyridin-2-yl)-N-(5-fluoropyridin-3-yl)-5-oxopyrrolidine-2-carboxamide |
| Purity: | ≥98% |
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