Jumonji/JARID2 Proteins and Enzymes

JARID2 (Jumonji/ARID domain-containing protein 2; also Jumonji [Japanese for cruciform/cross] and JMJ) is a 150-160 kDa member of the JMJ family of proteins. It is a nuclear complex coordinator that interacts with the G9a and GLP methyltransferases to repress gene transcription. JARID2 is expressed in mammalian embryonic neurons, megakaryocytes, hepatocytes and cardiomyocytes. Human JARID2 is 1246 amino acids (aa) in length. It contains an NLS (aa 1-131), a transcriptional repressor domain ...