MACF1 Proteins and Enzymes

MACF1, also known as microtubule-actin cross-linking factor 1, isoforms 1/2/3/5, consists of five isoforms of sizes 838.3 kDa, 620.4 kDa, 614.1 kDa, 606.2 kDa, and 670.1 kDa and is involved in binding and cross-linking actin to microtubules and may play a role in transporting organelles throughout the cell. Diseases and disorders such as hepatitis, neuroblastoma, bullous pemphigoid, and schizophrenia are being researched with this protein. The protein interacts with SKIL, GOLGA4, ATF7IP, DISC1, and DTNBP1.