MBP Proteins and Enzymes

Myelin Basic Protein (MBP) is the most abundant protein component of the myelin membrane in the central nervous system (CNS). Human MBP has 304 amino acids (aa) and shows 71% and 49% aa sequence identity with the mouse and rat orthologs, respectively. Alternative splicing of a single gene, and the optional posttranslational modification of different aa residues, produces a spectrum of isoforms that range in size from 14 kDa to 21.5 kDa. These isoforms exhibit different developmental and ...