Miz-1/ZBTB17 Proteins and Enzymes

Miz-1 (Myc-interacting zinc finger protein 1; also ZBTB17) is an 88 kDa, DNA-binding protein that belongs to the Kruppel C2H2-type zinc finger protein family. Human Miz-1 is 803 amino acids (aa) in length, and contains a POZ domain (aa 1-104), two Myc-interaction segments (aa 269-308 & 637-718), and 12 C2H2-type zinc finger motifs (aa 306-637); also, there is one alternate splice form that shows an eight aa substitution for Thr769. Miz-1 induces cell arrest at G₁, an effect mediated by its ...