1 result for "NEDD8 Small Molecules and Peptides" in Products

NEDD8 Small Molecules and Peptides

NEDD8 (Neural precursor cell-expressed developmentally down-regulated gene 8; also known as Rub1) is a 6-8 kDa member of the ubiquitin family of proteins. It is expressed in striated muscle, and via its C-terminal Gly, forms covalent bonds with cullin family proteins. This conjugation generates ubiquitin ligase activity that regulates cell cycle pr...

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Potent and selective NEDD8 activating enzyme (NAE) inhibitor; cell permeable

Alternate Names: Pevonedistat,TAK-924
Chemical Name: [(1S,2S,4R)-4-[4-[[(1S)-2,3-Dihydro-1H-inden-1-yl]amino]-7H-pyrrolo[2,3-d]pyrimidin-7-yl]-2-hydroxycyclopentyl]methyl sulfamic acid ester
Purity: ≥98%
Potent and selective NEDD8 activating enzyme (NAE) inhibitor; cell permeable
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