NHE3/SLC9A3 Proteins and Enzymes

Na(+)/H(+) exchanger 3 (NHE3), also known as SLC9A3, plays an important role in neutral Na(+) transport in mammalian epithelial cells. SLC9A3 is acutely up- and down-regulated in response to some G protein-coupled receptors, tyrosine kinase receptors, and protein kinases. It is involved in pH regulation to eliminate acids generated by active metabo...