NrCAM Proteins and Enzymes

NgCAM related cell adhesion molecule (NrCAM), also known as Bravo, belongs to the L1 family of cell adhesion molecules, which includes L1, neurofascin and close homolog of L1 (CHL-1/L1CAM-2). These molecules are type I transmembrane proteins that have six Ig-like domains and 4 to 5 Fibronectin type III-like domains in their extracellular region. They also share a conserved cytoplasmic region containing an ankyrin-binding site. L1 family cell adhesion molecules are expressed primarily in the nervous system where they share overlapping functions in controlling axonal growth and guidance.