PKN2 Proteins and Enzymes

Serine/Threonine Protein Kinases N1 and N2 are PKC family members that are downstream effectors of RhoA. Both promote the activation of several kinases involved in regulation of the actin cytoskeleton, cell cycle, and apoptosis. PKN1 can be activated by proteolysis, lipid interaction, or Rho G proteins. PKN2 cleavage during apoptosis generates a C-...