Proteasome Modulators Small Molecules and Peptides

The proteasome complex is a broad spectrum protease present in all eukaryotes, which functions to carry out selective, efficient and progressive hydrolysis of intracellular target proteins. The proteasome plays a prominent role in the control of a diverse array of basic cellular processes by rapidly catalyzing numerous biological reactions.

The proteasome complex is composed of a 20S catalytic core and one or two terminal 19S regulatory units. The 20S catalytic domain is barrel-shaped and ...