TAB1 Proteins and Enzymes

TAB1 is a 55 kDa scaffold protein that is involved a number of cytokine signaling pathways. It binds to TAK1 (MAPK kinase kinase 7), a downstream signaling molecule associated with both TGF-beta and inflammatory cytokine activity. TAB1 interaction with TAK1 promotes TAK1 autophosphorylation. It also has TAK1-independent signaling activity that invo...