Thimet Oligopeptidase/THOP1 Proteins and Enzymes

THOP1 (Thimet Oligopeptidase), also called metalloendopeptidase 24.15, is a soluble protease that is expressed ubiquitously, with highest levels in the brain. It degrades peptides released from proteasomes and neuropeptides under 20 amino acids in length. Depending on the cell type, it can be cytosolic, nuclear, secreted or membrane-associated.