Transcobalamin II Proteins and Enzymes

Transcobalamin II (TCII) is an approximately 44 kDa protein that serves as a circulating carrier for cobalt-containing Vitamin B12 (also known as Cobalamin, or Cbl). Vitamin B12 plays an important role as a coenzyme during amino acid and nucleotide metabolism. Chronic deficiency of Vitamin B12 intake, absorption, or transport leads to serious health risks including megaloblastic anemia and neurologic symptoms. Prior to its interaction with TCII, dietary Vitamin B12 is bound by salivary ...