TRH-degrading Ectoenzyme/TRHDE Proteins and Enzymes

TRHDE is a metalloprotease that specifically removes pyroglutamate from thyrotropin-releasing hormone (TRH). TRH functions as a hypothalamic hypophysiotropic neuropeptide and neurotransmitter/neuromodulator within the central nervous system. Because TRHDE inactivates TRH, TRHDE inhibitors have potential applications as research and therapeutic agents. TRHDE is a type II transmembrane protein and a soluble form is also present in the serum.