TRPC Channel Antagonists

TRPC channels are complexes formed by four subunits, each with 6-transmembrane domains and several common features such as 3 or 4 ankyrin repeats in the N-terminal and a TRP box motif at proximal C-terminal. These cation channels are activated, to varying extents, by phospholipase C signaling pathway components, downstream of G_q/11 G protein-coupled receptors (GPCRs) and receptor tyrosine kinases (RTKs). Activation of TRPC channels leads to cation influx, membrane depolarization and elevation ...