UCH-L1/PGP9.5 Luminex Assays

Ubiquitin Carboxyterminal Hydrolase Isozyme 1 (UCH-L1), also known as PGP9.5, is a cytoplasmic protein that belongs to the peptidase C12 family of enzymes. It is predominantly expressed in neurons in the brain and has only limited expression in other healthy tissue such as the gonads. However, UCH-L1/PGP.95 is found in high levels in several cancer cells types including pancreatic cancer, colorectal cancer, and breast cancer. UCH-L1/PGP.95 has dual enzymatic activity. As a monomer, it acts as ...