USAG1 Proteins and Enzymes

USAG1, also known as WISE, Ectodin, or SOSTDC1, is a secreted  glycoprotein of the sclerostin family. It binds and sequesters BMP-2, -4, -6, and -7, and it blocks LRP5 and LRP6 interaction with Wnt proteins. USAG1 co-localizes with BMP-7 in the developing and adult kidney, particularly in distal tubule epithelial cells. It is also found in ect...