4-CMTB

Key Product Details

Product Description

4-CMTB is a free fatty acid receptor FFA2 agonist (pEC₅₀ = 6.38) and positive allosteric modulator. Binds at a site distinct from the orthosteric site; modulates the activity of short-chain fatty acids at FFA2 via the FFA2 second extracellular loop (ECL2).

Product Specifications for 4-CMTB

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Solubility

Preparing Stock Solutions for 4-CMTB

The following data is based on the product molecular weight 294.80.

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which all affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:

1 Recalculate

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	3.39 mL	16.96 mL	33.92 mL
5 mM	0.68 mL	3.39 mL	6.78 mL
10 mM	0.34 mL	1.70 mL	3.39 mL
50 mM	0.07 mL	0.34 mL	0.68 mL

Calculators

Background References

References are publications that support the biological activity of the product. See our Citations tab to view 19 publications citing the usage of this product.

• Milligan Agonism and allosterism: the pharmacology of the free fatty acid receptors FFA2 and FFA3. Br.J.Pharmacol. 2009 PMID: 19719777
• Smith Extracellular loop 2 of the free fatty acid receptor 2 mediates allosterism of a phenylacetamide ago-allosteric modulator. Mol.Pharmacol. 2011 PMID: 21498659

Product Documents for 4-CMTB