8 results for "Free Fatty Acid Receptor Agonists" in 产品
Free Fatty Acid Receptor Agonists
Free Fatty Acid (FFA) receptors are a group of Gq/11 protein-coupled receptors that are currently classified into FFA1, FFA2, FFA3 and FFA4 subtypes. FFA receptors are concentrated in the pancreatic islet cells (particularly FFA1) and in the brain, with lower expression levels found in adipose tissue, peripheral blood mononuclear cells, neutrophils and monocytes.
FFAs 1, 2 and 3 genes are co-located on chromosome 19 and have closely related sequences, while FFA4 is located on chromosome 10 and ...
Potent and selective FFA4 (GPR120) agonist
| Chemical Name: | 4-[(4-Fluoro-4'-methyl[1,1'-biphenyl]-2-yl)methoxy]-benzenepropanoic acid |
| Purity: | ≥98% |
Potent and selective FFA1 (GPR40) agonist
| Chemical Name: | 4-[[(3-Phenoxyphenyl)methyl]amino]benzenepropanoic acid |
| Purity: | ≥98% |
FFA2 agonist; also exhibits positive allosteric modulatory activity
| Chemical Name: | 4-chloro-α-(1-methylethyl)-N-2-thiazolylbenzeneacetamide |
| Purity: | ≥98% |
Potent FFA1 (GPR40) partial agonist
| Chemical Name: | (βS)-β-1-Propyn-1-yl-4-[[4'-(trifluoromethyl)[1,1'-biphenyl]-3-yl]methoxy]benzenepropanoic acid hemicalcium salt |
| Purity: | ≥98% |
FFA3 agonist
| Chemical Name: | N-(2,5-Dichlorophenyl)-4-(furan-2-yl)-2-methyl-5-oxo-1,4,5,6,7,8-hexahydroquinoline-3-carboxamide |
| Purity: | ≥98% |
FFA2 allosteric agonist; displays bias for the Gi signaling pathway
| Chemical Name: | 4-Fluoro-N-[3-[2-[(aminoiminomethyl)amino]-4-methyl-5-thiazolyl]phenyl]benzamide |
| Purity: | ≥98% |
Potent and selective GPR84 agonist
| Chemical Name: | 3-(2-((4-Chloronaphthalen-1-yl)oxy)ethyl)pyridine 1-oxide |
| Purity: | ≥98% |
Potent allosteric FFA1 (GPR40) and 4 (GPR120) agonist
| Chemical Name: | 1-[3-[[4-Amino-6-[[2-(2,5-dichlorophenyl)ethyl]amino]-1,3,5-triazin-2-yl]methoxy]-5-methylphenyl]-2-pyrrolidinone |
| Purity: | ≥98% |
