5-BDBD

Tocris Bioscience | Catalog # 3579

Potent and selective P2X4 antagonist
Tocris Bioscience

Key Product Details

Description

Potent and selective P2X4 antagonist
View all P2X Receptor Antagonists »

Product Description

5-BDBD is a potent and selective P2X4 receptor antagonist. Blocks P2X4-mediated currents in Chinese hamster ovary cells (IC50 = 0.50 μM). Exhibits no significant antagonist effects at other P2X receptors. Reduces long-term potentiation (LTP) in rat hippocampal slices.

Product Specifications for 5-BDBD

Molecular Weight

355.19

Formula

C17H11BrN2O2

Storage

Store at RT

Purity

≥98% (HPLC)

Chemical Name

5-(3-Bromophenyl)-1,3-dihydro-2H-benzofuro[3,2-e]-1,4-diazepin-2-one

CAS Number

768404-03-1

PubChem ID

9841560

InChI Key

NKYMVQPXXTZHSF-UHFFFAOYSA-N

SMILES

BrC1=CC(C(C3=C4C2=C(O3)C=CC=C2)=NCC(N4)=O)=CC=C1

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Solubility

Solvent Max Conc. mg/mL Max Conc. mM
Solubility
DMSO 35.52 100

Preparing Stock Solutions for 5-BDBD

The following data is based on the product molecular weight 355.19.

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which all affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:

Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 2.82 mL 14.08 mL 28.15 mL
5 mM 0.56 mL 2.82 mL 5.63 mL
10 mM 0.28 mL 1.41 mL 2.82 mL
50 mM 0.06 mL 0.28 mL 0.56 mL

Calculators

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Background References

References are publications that support the biological activity of the product. See our Citations tab to view 110 publications citing the usage of this product.

Product Documents for 5-BDBD

Certificate of Analysis

To download a Certificate of Analysis, please enter a lot or batch number in the search box below.

Product Specific Notices for 5-BDBD

For research use only

Customer Reviews for 5-BDBD (1)

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  • Good inhibitor
    Name: Stefan Uderhardt
    Species: Mouse
    Assay Type: In Vivo
    Cell Line/Tissue: phagocyte
    Verified Customer | Posted 06/06/2020
    DMSO dilution 10 μM
    5-BDBD 3579

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