680C91

Key Product Details

Product Description

680C91 is a potent and selective inhibitor of tryptophan 2,3-dioxygenase (TDO) (K_i = 51 nM). Exhibits no activity against indoleamine 2,3-dioxygenase, monoamine oxidase A and B, 5-HT uptake or 5-HT_1A, _1D, _2A and _2C receptors. Produces large increases in brain tryptophan and serotonin in vitro and in vivo in the rat.

Product Specifications for 680C91

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Solubility

Preparing Stock Solutions for 680C91

The following data is based on the product molecular weight 238.26.

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which all affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:

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Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	4.20 mL	20.99 mL	41.97 mL
5 mM	0.84 mL	4.20 mL	8.39 mL
10 mM	0.42 mL	2.10 mL	4.20 mL
50 mM	0.08 mL	0.42 mL	0.84 mL

Calculators

Background References

References are publications that support the biological activity of the product. See our Citations tab to view 12 publications citing the usage of this product.

• Salter The effects of an inhibitor of tryptophan 2,3-dioxygenase and a combined inhibitor of tryptophan 2,3-dioxygenase and 5-HT reuptake in the rat. Neuropharmacology 1995 PMID: 7617147
• Opitz An endogenous tumour-promoting ligand of the human aryl hydrocarbon receptor. Nature 2011 PMID: 21976023
• Salter The effects of a novel and selective inhibitor of tryptophan 2,3-dioxygenase on tryptophan and serotonin metabolism in the rat. Biochem.Pharmacol. 1995 PMID: 7539265

Product Documents for 680C91