Tryptophan 2,3 Dioxygenase Inhibitors

Tryptophan 2,3 dioxygenase (TDO, EC 1.13.11.11) is a heme-containing oxidoreductase which catalyzes the rate-limiting first step of the kynurenine pathway; the oxidative cleavage of L-tryptophan (L-Trp) into N-formyl-kynurenine (Nfk).

Primarily localized to the liver, where its main function is to regulate L-Trp homeostasis in the blood, TDO is responsible for the majority of L-Trp degradation via the kynurenine pathway. This leads to the production of L-Trp metabolites and the synthesis of ...