A 410099.1, amine

Name: A 410099.1, amine
Brand: Tocris Bioscience
SKU: 6471
Price: 665 USD
Availability: InStock

Tocris Bioscience | Catalog # 6471

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Citations (16)

Product Documents

Functionalized IAP ligand for PROTACs

Product Description
Product Specifications
Calculators
Background References
Product Documents
Specific Notices

Key Product Details

Description

Functionalized IAP ligand for PROTACs

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Product Description

A 410099.1, amine is a functionalized IAP ligand for PROTAC^® research and development. Boc protected A 410099.1 (Cat.No. 6470). Supplied with an amine functional handle for ready conjugation to a linker/target protein ligand. NanoBRET assays show EC₅₀ values of 4.6, 9.2 and 15.6 nM for cIAP1, cIAP2 and XIAP proteins, respectively. Part of a range of functionalized tool molecules for PROTAC R&D.

Please contact us for SD files of our available Degrader Building Blocks.

PROTAC^® is a registered trademark of Arvinas Operations, Inc., and is used under license.

Usage Guidelines

This product is provided for use in onward chemistry. Suitable solvents can be used.

Product Specifications for A 410099.1, amine

Molecular Weight

620.22

Formula

C₃₂H₄₉N₅O₅.HCl

Storage

Store at -20°C

Purity

≥98% (HPLC)

Chemical Name

tert-Butyl [(S)-1-[[(S)-2-[(2S,4S)-4-amino-2-[[(R)-1,2,3,4-tetrahydronaphthalen-1-yl]carbamoyl]pyrrolidin-1-yl]-1-cyclohexyl-2-oxoethyl]amino]-1-oxopropan-2-yl](methyl)carbamate hydrochloride

CAS Number

2374122-37-7

InChI Key

XWVNETXEAKCZET-CZNZTGDVSA-N

SMILES

C[C@@H](C(N[C@H](C(N1C[C@H](C[C@H]1C(N[C@@H]2CCCC3=CC=CC=C23)=O)N)=O)C4CCCCC4)=O)N(C(OC(C)(C)C)=O)C.Cl

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Calculators

Calculate the mass, volume, or concentration required for a solution.

Mass

Concentration

音量

M. Wt*

g/mol

*When preparing stock solutions always use the batch-specific molecular weight of the product found on the vial label and CoA (available online).

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Concentration 1 (C1)

Volume 1 (V1)

Concentration 2 (C2)

Volume 2 (V2)

The reconstitution calculator allows you to quickly calculate the volume of a reagent to reconstitute your vial. Simply enter the mass of reagent and the target concentration and the calculator will determine the rest.

Volume (to add to vial)

Mass (in vial)

Desired Reconstitution Concentration

Background References

References are publications that support the biological activity of the product. See our Citations tab to view 16 publications citing the usage of this product.

Schwalm A toolbox for the generation of chemical probes for baculovirus IAP repeat containing proteins. Front.Cell.Dev.Biol. 2022 PMID: 35721509
Tinworth PROTAC-mediated degradation of Bruton's tyrosine kinase is inhibited by covalent binding. ACS Chem.Biol. 2019 PMID: 30807093

Product Documents for A 410099.1, amine

Download SDS

Product Specific Notices for A 410099.1, amine

For research use only

Citations for A 410099.1, amine

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