A 425619

Tocris Bioscience | Catalog # 5781

Potent TRPV1 antagonist
Tocris Bioscience

Key Product Details

Description

Potent TRPV1 antagonist
View all TRPV Antagonists »

Product Description

A 425619 is a potent TRPV1 antagonist (IC50 = 3-9 nM). Blocks capsaicin-evoked currents in rat DRG neurons and inhibits TRPV1-activation by anandamide (Cat. No. 1339) and N-arachidonoyl-dopamine. Reduces pain in inflammatory, postoperative and osteoarthritic in vivo pain models.

Product Specifications for A 425619

Molecular Weight

345.32

Formula

C18H14F3N3O

Storage

Store at RT

Purity

≥98% (HPLC)

Chemical Name

N-5-Isoquinolinyl-N'-[[(4-(trifluoromethyl)phenyl]methyl]urea

CAS Number

581809-67-8

PubChem ID

8068410

InChI Key

SJGVXVZUSQLLJB-UHFFFAOYSA-N

SMILES

O=C(NCC1=CC=C(C(F)(F)F)C=C1)NC2=CC=CC3=CN=CC=C32

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Solubility

Solvent Max Conc. mg/mL Max Conc. mM
Solubility
DMSO 34.53 100
Ethanol 34.53 100

Preparing Stock Solutions for A 425619

The following data is based on the product molecular weight 345.32.

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which all affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:

Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 2.90 mL 14.48 mL 28.96 mL
5 mM 0.58 mL 2.90 mL 5.79 mL
10 mM 0.29 mL 1.45 mL 2.90 mL
50 mM 0.06 mL 0.29 mL 0.58 mL

Calculators

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Background References

References are publications that support the biological activity of the product. See our Citations tab to view 11 publications citing the usage of this product.

Product Documents for A 425619

Certificate of Analysis

To download a Certificate of Analysis, please enter a lot or batch number in the search box below.

Product Specific Notices for A 425619

For research use only

Related Research Areas

Ion Channels and Regulators

Customer Reviews for A 425619 (1)

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  • Inhibiting calcium entry in human mast cells stimulated with cortistatin
    Name: ANANTH KUMAR KAMMALA
    Species: Human
    Assay Type: In Vitro
    Cell Line/Tissue: LAD2 - mast cells
    Verified Customer | Posted 01/30/2021
    A425619 product was used to study the role of MrgprX2 receptor in calcium mobilization in human mast cells. At a concentration of 0.01 and 0.03uM A425619 inhibited calcium entry significantly when stimulated mast cells with cortistatin.
    A 425619 5781

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