A 740003

Tocris Bioscience | Catalog # 3701

Potent and selective P2X7 antagonist
Tocris Bioscience

Key Product Details

Description

Potent and selective P2X7 antagonist
View all P2X Receptor Antagonists »

Product Description

A 740003 is a potent and selective P2X7 receptor antagonist (IC50 values are 18 and 40 nM for rat and human receptors respectively). Displays selectivity over a variety of P2X and P2Y receptors up to a concentration of 100 μM. Reduces nociception in animal models of persistent neuropathic and inflammatory pain. Also reduces neuroblastoma tumor growth in mice.

Product Specifications for A 740003

Molecular Weight

474.55

Formula

C26H30N6O3

Storage

Store at +4°C

Purity

≥97% (HPLC)

Chemical Name

N-[1-[[(Cyanoamino)(5-quinolinylamino)methylene]amino]-2,2-dimethylpropyl]-3,4-dimethoxybenzeneacetamide

CAS Number

861393-28-4

PubChem ID

11351968

InChI Key

PUHSRMSFDASMAE-UHFFFAOYSA-N

SMILES

CC(C)(C)C(NC(CC3=CC(OC)=C(OC)C=C3)=O)N/C(NC2=CC=CC1=NC=CC=C12)=N/C#N

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Solubility

Solvent Max Conc. mg/mL Max Conc. mM
Solubility
DMSO 9.49 20

Preparing Stock Solutions for A 740003

The following data is based on the product molecular weight 474.55.

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which all affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:

Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
0.2 mM 10.54 mL 52.68 mL 105.36 mL
1 mM 2.11 mL 10.54 mL 21.07 mL
2 mM 1.05 mL 5.27 mL 10.54 mL
10 mM 0.21 mL 1.05 mL 2.11 mL

Calculators

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Background References

References are publications that support the biological activity of the product. See our Citations tab to view 101 publications citing the usage of this product.

Product Documents for A 740003

Certificate of Analysis

To download a Certificate of Analysis, please enter a lot or batch number in the search box below.

Product Specific Notices for A 740003

For research use only

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