Acyclovir

Tocris Bioscience | Catalog # 2513

Inhibits viral DNA polymerase; antiherpetic agent
Tocris Bioscience
Discontinued Product
2513 has been discontinued. View all RNA/DNA Polymerase Inhibitors products.

Key Product Details

Description

Inhibits viral DNA polymerase; antiherpetic agent

Alternative Names

Aciclovir,Acycloguanosine
View all RNA/DNA Polymerase Inhibitors »

Product Description

Acyclovir is an antiviral agent, active against herpes simplex viruses HSV-1 and HSV-2 (EC50 values are 0.85 and 0.86 μM respectively). Interferes with viral DNA polymerization through competitive inhibition with guanosine triphosphate. Induces apoptosis in cells transfected with HSV-TK (suicidal gene therapy).

Product Specifications for Acyclovir

Molecular Weight

225.21

Formula

C8H11N5O3

Storage

Store at RT

Purity

≥99% (HPLC)

Chemical Name

2-Amino-1,9-dihydro-9-[(2-hydroxyethoxy)methyl]-6H-purin-6-one

CAS Number

59277-89-3

PubChem ID

2022

InChI Key

MKUXAQIIEYXACX-UHFFFAOYSA-N

SMILES

NC1=NC(=O)C2=C(N1)N(COCCO)C=N2

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Solubility

Solvent Max Conc. mg/mL Max Conc. mM
Solubility
1eq. HCl 11.26 50
DMSO 4.5 20

Preparing Stock Solutions for Acyclovir

The following data is based on the product molecular weight 225.21.

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which all affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:

Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
0.5 mM 8.88 mL 44.40 mL 88.81 mL
2.5 mM 1.78 mL 8.88 mL 17.76 mL
5 mM 0.89 mL 4.44 mL 8.88 mL
25 mM 0.18 mL 0.89 mL 1.78 mL

Calculators

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Background References

References are publications that support the biological activity of the product. See our Citations tab to view 6 publications citing the usage of this product.

Product Documents for Acyclovir

Certificate of Analysis

To download a Certificate of Analysis, please enter a lot or batch number in the search box below.

Product Specific Notices for Acyclovir

For research use only

Related Research Areas

Epigenetics

Customer Reviews for Acyclovir (1)

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  • Acyclovir was studied in conjunction with few contemporary chemotherapy strategies
    Name: Anonymous
    Species: Human
    Verified Customer | Posted 08/18/2019
    Acyclovir's effect was seen to increased when used with certain other medicines namely chemotherapeutic. Acyclovir was studied in conjunction with few contemporary chemotherapy strategies.
    Acyclovir 2513

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