Product Description
AM 12 is a TRPC5 inhibitor (IC50 = 0.28 μM); Galangin (Cat. No. 6494) derivative. Exhibits some selectivity for TRPC5 over TRPC2, 3 and 4. Inhibits effects of TRPC5 activator (-)-Englerin A, but potentiates effects of physiological activators Sphingosine-1-phosphate (Cat. No.1370) and LPC.
Product Specifications for AM 12
Molecular Weight
Formula
Storage
Purity
Chemical Name
CAS Number
PubChem ID
InChI Key
SMILES
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Solubility
| Solvent | Max Conc. mg/mL | Max Conc. mM | |
|---|---|---|---|
| Solubility | |||
| DMSO | 34.91 | 100 | |
| Ethanol | 17.46 | 50 |
Preparing Stock Solutions for AM 12
The following data is based on the product molecular weight 349.14.
Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which all affect the solvent volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 1 mM | 2.86 mL | 14.32 mL | 28.64 mL |
| 5 mM | 0.57 mL | 2.86 mL | 5.73 mL |
| 10 mM | 0.29 mL | 1.43 mL | 2.86 mL |
| 50 mM | 0.06 mL | 0.29 mL | 0.57 mL |
Calculators
Background References
References are publications that support the biological activity of the product.
- Naylor Natural and synthetic flavonoid modulation of TRPC5 channels. Br.J.Pharmacol. 2016 PMID: 26565375
Product Documents for AM 12
Certificate of Analysis
To download a Certificate of Analysis, please enter a lot or batch number in the search box below.
Product Specific Notices for AM 12
For research use only
Related Research Areas
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