Anisomycin

Tocris Bioscience | Catalog # 1290

JNK, SAPK and p38 activator
Tocris Bioscience

Key Product Details

Description

JNK, SAPK and p38 activator
View all JNK/c-jun Activators »

Product Description

Anisomycin is a protein synthesis inhibitor (blocks translation). Potent activator of stress-activated protein kinases (JNK/SAPK) and p38 MAP kinase. Acts as a potent signaling agonist to selectively elicit homologous desensitization of immediate early gene induction (c-fos, fosB, c-jun, junB and junD).

Product Specifications for Anisomycin

Molecular Weight

265.31

Formula

C14H19NO4

Storage

Store at +4°C

Purity

≥98% (HPLC)

Chemical Name

(2R,3S,4S)-2-[(4-Methoxyphenyl)methyl]-3,4-pyrrolidinediol 3-acetate

CAS Number

22862-76-6

PubChem ID

253602

InChI Key

YKJYKKNCCRKFSL-RDBSUJKOSA-N

SMILES

O[C@H]1CN[C@H](CC2=CC=C(OC)C=C2)[C@@H]1OC(C)=O

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Solubility

Solvent Max Conc. mg/mL Max Conc. mM
Solubility
DMSO 26.53 100
Ethanol 13.27 50

Preparing Stock Solutions for Anisomycin

The following data is based on the product molecular weight 265.31.

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which all affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:

Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 3.77 mL 18.85 mL 37.69 mL
5 mM 0.75 mL 3.77 mL 7.54 mL
10 mM 0.38 mL 1.88 mL 3.77 mL
50 mM 0.08 mL 0.38 mL 0.75 mL

Calculators

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Product Documents for Anisomycin

Certificate of Analysis

To download a Certificate of Analysis, please enter a lot or batch number in the search box below.

Product Specific Notices for Anisomycin

For research use only

Customer Reviews for Anisomycin (1)

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  • Increase p38 MAPK activity
    Name: Anonymous
    Assay Type: In Vitro
    Verified Customer | Posted 11/02/2017
    We use anisomycin to increrase p38 MAPK activity, though it can also be used to block protein synthesis.

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