Apocynin
Tocris Bioscience | Catalog # 4663
Product Description
Apocynin is an NADPH oxidase inhibitor. Demonstrates anti-inflammatory properties in a mouse model of carrageenan-induced pleurisy. Apocynin is bioactivated by intracellular peroxidases; acts as an antioxidant in endothelial cells and vascular smooth muscle cells.
Product Specifications for Apocynin
Molecular Weight
Formula
Storage
Purity
Chemical Name
CAS Number
PubChem ID
InChI Key
SMILES
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Solubility
| Solvent | Max Conc. mg/mL | Max Conc. mM | |
|---|---|---|---|
| Solubility | |||
| DMSO | 16.62 | 100 | |
| Ethanol | 16.62 | 100 |
Preparing Stock Solutions for Apocynin
The following data is based on the product molecular weight 166.17.
Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which all affect the solvent volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 1 mM | 6.02 mL | 30.09 mL | 60.18 mL |
| 5 mM | 1.20 mL | 6.02 mL | 12.04 mL |
| 10 mM | 0.60 mL | 3.01 mL | 6.02 mL |
| 50 mM | 0.12 mL | 0.60 mL | 1.20 mL |
Calculators
Background References
References are publications that support the biological activity of the product. See our Citations tab to view 41 publications citing the usage of this product.
- Impellizzeri Effect of apocynin, a NADPH oxidase inhibitor, on acute lung inflammation. Biochem.Pharmacol. 2011 PMID: 21147071
- Heumüller Apocynin is not an inhibitor of vascular NADPH oxidases but an antioxidant. Hypertension 2008 PMID: 18086956
- Stolk Characteristics of the inhibition of NADPH oxidase activation in neutrophils by apocynin, a methoxy-substituted catechol. Am.J.Respir.Cell Mol.Biol. 1994 PMID: 8018341
Product Documents for Apocynin
Certificate of Analysis
To download a Certificate of Analysis, please enter a lot or batch number in the search box below.
Product Specific Notices for Apocynin
For research use only
Related Research Areas
Citations for Apocynin
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Species: RatAssay Type: Ex VivoCell Line/Tissue: brain sliceVerified Customer | Posted 01/10/2018Apocynin is a NADPH oxidase inhibitor. It blocks NADPH oxidase in rat brain slice at 1mM.
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