Apolipoprotein E R2/ApoE R2 Antibody (S03-1H8)

Novus Biologicals | Catalog # NBP3-19571

Recombinant Monoclonal Antibody
Novus Biologicals
100% Guarantee

Key Product Details

Species Reactivity

Human, Mouse, Rat

Applications

Western Blot

Label

Unconjugated

Antibody Source

Recombinant Monoclonal Rabbit IgG Clone # S03-1H8 expressed in HEK293
View all Apolipoprotein E R2/ApoE R2 Primary Antibodies »

Product Specifications

Immunogen

A synthetic peptide of human Apolipoprotein E R2/ApoE R2 (Uniprot # Q14114)

Clonality

Monoclonal

Host

Rabbit

Isotype

IgG

Scientific Data Images for Apolipoprotein E R2/ApoE R2 Antibody (S03-1H8)

Western Blot: Apolipoprotein E R2/ApoE R2 Antibody (S03-1H8) [NBP3-19571]

Western Blot: Apolipoprotein E R2/ApoE R2 Antibody (S03-1H8) [NBP3-19571]

Western Blot: Apolipoprotein E R2/ApoE R2 Antibody (S03-1H8) [NBP3-19571] - Western blot detection of Apolipoprotein E R2/ApoE R2 in CHO-K1, C6 cell lysates using NBP3-19571 (1:500 diluted). Predicted band size: 106kDa. Observed band size: 130106kDa.

Applications for Apolipoprotein E R2/ApoE R2 Antibody (S03-1H8)

Application
Recommended Usage

Western Blot

1/1000-1/5000

Formulation, Preparation, and Storage

Purification

Affinity purified

Formulation

50mM Tris-Glycine(pH 7.4), 0.15M NaCl, 40% Glycerol, 0.05% BSA

Preservative

0.01% Sodium Azide

Concentration

0.3 mg/ml

Shipping

The product is shipped with polar packs. Upon receipt, store it immediately at the temperature recommended below.

Stability & Storage

Store at 4C short term. Aliquot and store at -20C long term. Avoid freeze-thaw cycles.

Background: Apolipoprotein E R2/ApoE R2

Apolipoprotein E Receptor 2 (ApoER2), also known as LRP8, is a Low-density lipoprotein receptor family member involved in endocytosis and signal transduction. Specifically, ApoER-2 is responsible for the cellular recognition and internalization of ApoE containing lipoproteins, including VLDL and HDL.

ApoER2 is expressed mainly in the brain, placenta, platelets and megakaryocytic cells, but not in the liver. LRP8 mutations can cause myocardial infarction type 1 (MCI1), a condition characterized by the irreversible necrosis of heart muscle secondary to prolonged ischemia. ApoER2 may also play a role in debilitating neurodegenerative diseases such as schizophrenia and Alzheimer's disease.

ApoER2 antibodies are useful tools for studying certian cardiac and neurodegenerative diseases.

Long Name

Apolipoprotein E Receptor 2

Alternate Names

ApoER2, Lr8b, LRP-8, LRP8

Gene Symbol

LRP8

Additional Apolipoprotein E R2/ApoE R2 Products

Product Documents for Apolipoprotein E R2/ApoE R2 Antibody (S03-1H8)

Certificate of Analysis

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Product Specific Notices for Apolipoprotein E R2/ApoE R2 Antibody (S03-1H8)

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

Related Research Areas

Glucose Homeostasis
Obesity

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