AUTAC4

Key Product Details

Product Description

AUTAC4 is an autophagy-targeting chimera targeting mitochondria. Comprises p-fluorobenzyl guanine joined by a PEG linker to a 2-phenylindole-3-glyoxyaminde ligand for the translocator protein on the outer mitochondrial membrane. It delivers a guanine tag to the mitochondrial membrane and promotes mitophagy of damaged mitochondria. In Down syndrome cells, AUTAC4 degrades impaired mitochondria and promotes the generation of functionally normal mitochondria.

Licensing Information

Sold under license from Tohoku Techno Arch.

Product Specifications for AUTAC4

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Solubility

Preparing Stock Solutions for AUTAC4

The following data is based on the product molecular weight 869.97.

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which all affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:

1 Recalculate

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
0.2 mM	5.75 mL	28.74 mL	57.47 mL
1 mM	1.15 mL	5.75 mL	11.49 mL
2 mM	0.57 mL	2.87 mL	5.75 mL
10 mM	0.11 mL	0.57 mL	1.15 mL

Calculators

Background References

References are publications that support the biological activity of the product.

• Takahashi AUTACs: cargo-specific degraders using selective autophagy. Mol.Cell. 2019 PMID: 31606272

Product Documents for AUTAC4