108 results for "Active Degraders" in 产品

Active Degraders

IRAK3 Degrader 23
Catalog #: 7983
Product Documents
Images (1)

IRAK3 Degrader (PROTAC®

Chemical Name: 2-(2,6-Dioxo-3-piperidyl)-5-[4-[2-[1-[4-[4-[cis-4-[(5-isopropylpyrrolo[2,1-f][1,2,4]triazin-4-yl)amino]cyclohexyl]-piperazin-1-yl]-4-oxo-butanoyl]-4-piperidyl]ethyl]piperazin-1-yl]-isoindoline-1,3-dione
Purity: ≥98%
IRAK3 PROTAC® Degrader

α1A-AR Degrader 9c
Catalog #: 7278
Product Documents
Images (1)

Selective α1A adrenergic receptor Degrader (PROTAC®)

Chemical Name: 2-(2-(2-(2-(4-(4-(4-Amino-6,7-dimethoxyquinazolin-2-yl)piperazine-1-carbonyl)-1H-1,2,3-triazol-1-yl)ethoxy)ethoxy)ethoxy)-N-(2-(2,6-dioxopiperidin-3-yl)-1,3-dioxoisoindolin-4-yl)acetamide
Purity: ≥98%
Selective α1A adrenergic receptor Degrader (PROTAC®)

HDAC4 CHDI Degrader 11
Catalog #: 7882
Product Documents
Images (1)

Potent and selective HDAC4 Degrader (PROTAC®)

Chemical Name: (2S,4R)-1-((3R,26S)-26-(tert-Butyl)-3-methyl-1,24-dioxo-5-propyl-1-(4-(5-(trifluoromethyl)-1,2,4-oxadiazol-3-yl)phenyl)-10,13,16,19,22-pentaoxa-2,5,25-triazaheptacosan-27-oyl)-4-hydroxy-N-(4-(4-methylthiazol-5-yl)benzyl)pyrrolidine-2-carboxamide
Purity: ≥98%
Potent and selective HDAC4 Degrader (PROTAC®)

hCAII Degrader 11
Catalog #: 7964
Product Documents
Images (1)

Potent human carbonic anhydrase II Degrader (PROTAC®)

Chemical Name: 4-(Aminosulfonyl)-N-[12-[[2-(2,6-dioxo-3-piperidinyl)-2,3-dihydro-1,3-dioxo-1H-isoindol-4-yl]amino]dodecyl]benzamide
Purity: ≥98%
Potent human carbonic anhydrase II degrader

α-Synuclein Degrader 2b
Catalog #: 8040
Citations (1)
Product Documents
Images (1)

α-synuclein Degrader (PROTAC®)

Chemical Name: 2-[[3-[5-(1,3-Benzodioxol-5-yl)-1H-pyrazol-3-yl]phenyl]amino]-N-[2-[2-[2-[2-[[2-(2,6-dioxo-3-piperidinyl)-2,3-dihydro-1,3-dioxo-1H-isoindol-4-yl]amino]ethoxy]ethoxy]ethoxy]ethyl]acetamide
Purity: ≥98%
α-synuclein PROTAC® Degrader

STING Degrader SP23
Catalog #: 8053
Product Documents
Images (1)

Selective STING Degrader (PROTAC®)

Chemical Name: (2E)-N1-[6-[[2-(2,6-Dioxo-3-piperidinyl)-2,3-dihydro-1,3-dioxo-1H-isoindol-4-yl]amino]hexyl]-N4-[4-[[(5-nitro-2-furanyl)carbonyl]amino]phenyl]-2-butenediamide
Purity: ≥98%
Selective STING Degrader (PROTAC®)

dTAGV-1
Catalog #: 6914
(2)
Citations (67)
Product Documents
Images (1)

Potent and selective degrader of mutant FKBP12F36V fusion proteins

Chemical Name: (R)-3-(3,4-Dimethoxyphenyl)-1-(2-(2-((7-(((S)-1-((2S,4R)-4-hydroxy-2-(((S)-1-(4-(4-methylthiazol-5-yl)phenyl)ethyl)carbamoyl)pyrrolidin-1-yl)-3,3-dimethyl-1-oxobutan-2-yl)amino)-7-oxoheptyl)amino)-2-oxoethoxy)phenyl)propyl (S)-1-((S)-2-(3,4,5-trimethoxyphenyl)butanoyl)piperidine-2-carboxylate trifluoroacetate
Purity: ≥98%
Potent and selective degrader of mutant FKBP12F36V fusion proteins

dTAG-13
Catalog #: 6605
(4)
Citations (120)
Product Documents
Images (1)

Degrades mutant FKBP12F36V fusion proteins; useful alternative to genetic methods for target validation

Chemical Name: 1-[(2S)-1-Oxo-2-(3,4,5-trimethoxyphenyl)butyl]-(2S)-2-piperidinecarboxylate (1R)-3-(3,4-dimethoxyphenyl)-1-[2-[2-[[6-[[2-(2,6-dioxo-3-piperidinyl)-2,3-dihydro-1,3-dioxo-1H-isoindol-4-yl]oxy]hexyl]amino]-2-oxoethoxy]phenyl]propyl ester
Purity: ≥98%
Degrades mutant FKBP12F36V fusion proteins; useful alternative to genetic methods for target validation

MZ 1
Catalog #: 6154
Citations (25)
Product Documents
Images (2)

(+)-JQ1 based Degrader (PROTAC®) that preferentially degrades BRD4

Chemical Name: (2S,4R)-1-((S)-2-(tert-butyl)-17-((S)-4-(4-chlorophenyl)-2,3,9-trimethyl-6H-thieno[3,2-f][1,2,4]triazolo[4,3-a][1,4]diazepin-6-yl)-4,16-dioxo-6,9,12-trioxa-3,15-diazaheptadecanoyl)- 4-hydroxy-N-(4-(4-methylthiazol-5-yl)benzyl)pyrrolidine-2-carboxamide
Purity: ≥98%
Application of MZ 1 in HeLa Cells
(2)

5-Ph-IAA
Catalog #: 7392
Citations (9)
Product Documents
Images (1)

Selective and potent TAG Degrader for auxin-inducible degron 2 system

Chemical Name: 5-Phenyl-1H-indole-3-acetic acid
Purity: ≥98%
Selective and potent TAG Degrader for auxin-inducible degron 2 system

dBET6
Catalog #: 6945
Citations (7)
Product Documents
Images (1)

Potent and selective (+)-JQ1 based Degrader (PROTAC®) targeting BET bromodomains, active in vivo

Chemical Name: (6S)-4-(4-Chlorophenyl)-N-[8-[[2-[[2-(2,6-dioxo-3-piperidinyl)-2,3-dihydro-1,3-dioxo-1H-isoindol-4-yl]oxy]acetyl]amino]octyl]-2,3,9-trimethyl-6H-thieno[3,2-f][1,2,4]triazolo[4,3-a][1,4]diazepine-6-acetamide
Purity: ≥98%
Potent and selective (+)-JQ1 based Degrader (PROTAC®) targeting BET bromodomains, active in vivo

dTAG-47
Catalog #: 7530
Citations (4)
Product Documents
Images (1)

Degrades mutant FKBP12F36V fusion proteins; useful alternative to genetic methods for target validation

Chemical Name: (1R)-3-(3,4-Dimethoxyphenyl)-1-(2-(2-((8-((2-(2,6-dioxopiperidin-3-yl)-1,3-dioxoisoindolin-5-yl)amino)octyl)amino)-2-oxoethoxy)phenyl)propyl (2S)-1-((S)-2-(3,4,5-trimethoxyphenyl)butanoyl)piperidine-2-carboxylate
Purity: ≥97%
Degrades mutant FKBP12F36V fusion proteins; useful alternative to genetic methods for target validation

dBRD9
Catalog #: 6606
Citations (17)
Product Documents
Images (1)

Potent and selective BRD9 Degrader (PROTAC®)

Chemical Name: 2-[[[4-(1,2-Dihydro-2-methyl-1-oxo-2,7-naphthyridin-4-yl)-2-6-dimethoxyphenyl]methyl]methylamino]-N-[2-[2-[2-[[2-(2,6-dioxo-3-piperidinyl)-2,3-dihydro-1,3-dioxo-1H-isoindol-4-yl]amino]ethoxy]ethoxy]ethyl]acetamide dihydrochloride
Purity: ≥98%
Potent and selective BRD9 Degrader (PROTAC®)

xStAx-VHLL
Catalog #: 7298
Product Documents
Images (1)

Selective peptide-based β-catenin Degrader (PROTAC®)

Purity: ≥95%
Selective peptide-based β-catenin Degrader (PROTAC®)

dBET1
Catalog #: 6327
Citations (3)
Product Documents
Images (1)

(+)-JQ1 based Degrader (PROTAC®) targeting BET bromodomains, active in vivo

Chemical Name: (6S)-4-(4-Chlorophenyl)-N-[4-[[2-[[2-(2,6-dioxo-3-piperidinyl)-2,3-dihydro-1,3-dioxo-1H-isoindol-4-yl]oxy]acetyl]amino]butyl]-2,3,9-trimethyl-6H-thieno[3,2-f][1,2,4]triazolo[4,3-a][1,4]diazepine-6-acetamide
Purity: ≥98%
(+)-JQ1 based Degrader (PROTAC®) targeting BET bromodomains, active in vivo

NR 7h
Catalog #: 7177
Product Documents
Images (1)

Potent and selective p38α and p38β Degrader (PROTAC®); active in vivo

Chemical Name: 3-(3-Bromo-4-((2,4-difluorobenzyl)oxy)-6-methyl-2-oxopyridin-1(2H)-yl)-N-(4-(1-(4-((4-((2-(2,6-dioxopiperidin-3-yl)-1,3-dioxoisoindolin-4-yl)amino)butyl)amino)-4-oxobutyl)-1H-1,2,3-triazol-4-yl)butyl)-4-methylbenzamide
Purity: ≥97%
Potent and selective p38α and p38β Degrader (PROTAC®); active in vivo

dBRD9-A
Catalog #: 6943
Citations (3)
Product Documents
Images (1)

Potent BRD9 Degrader (PROTAC®)

Chemical Name: 2-((2,6-Dimethoxy-4-(2-methyl-1-oxo-1,2-dihydro-2,7-naphthyridin-4-yl)benzyl)(methyl)amino)-N-(8-((2-(2,6-dioxopiperidin-3-yl)-1,3-dioxoisoindolin-4-yl)amino)octyl)acetamide
Purity: ≥98%
Potent BRD9 Degrader (PROTAC®)

CRBN-6-5-5-VHL
Catalog #: 6948
Product Documents
Images (2)

Potent and selective cereblon Degrader (PROTAC®); cell-permeable

Chemical Name: (2S,4R)-1-((2S)-2-(5-((5-((6-((2-(2,6-Dioxopiperidin-3-yl)-1,3-dioxoisoindolin-4-yl)amino)hexyl)oxy)pentyl)oxy)pentanamido)-3,3-dimethylbutanoyl)-4-hydroxy-N-(4-(4-methylthiazol-5-yl)benzyl)pyrrolidine-2-carboxamide
Purity: ≥96%
Application of CRBN-6-5-5-VHL in MM1S cells for CRBN-6-5-5-VHL
(2)

DD 03-171
Catalog #: 7160
Citations (2)
Product Documents
Images (1)

Potent and selective BTK Degrader (PROTAC®)

Chemical Name: 4-(1,1-Dimethylethyl)-N-[3-[6-[[4-[[4-[6-[[2-[[2-(2,6-dioxo-3-piperidinyl)-2,3-dihydro-1,3-dioxo-1H-isoindol-4-yl]amino]acetyl]amino]hexyl]-1-piperazinyl]carbonyl]phenyl]amino]-4,5-dihydro-4-methyl-5-oxo-2-pyrazinyl]-2-methylphenyl]benzamide
Purity: ≥98%
Potent and selective BTK Degrader (PROTAC®)

ND1-YL2
Catalog #: 7388
Product Documents
Images (1)

SRC-1 peptide-based Degrader (PROTAC®); active in vivo

Purity: ≥95%
SRC-1 peptide-based PROTAC®; active in vivo

CRBN PROTAC® 14a
Catalog #: 7219
Product Documents
Images (1)

Cereblon Degrader (PROTAC®)

Chemical Name: N1-(2-((2-(2,6-Dioxopiperidin-3-yl)-1,3-dioxoisoindolin-4-yl)amino)ethyl)-N20-((S)-1-((2S,4R)-4-hydroxy-2-((4-(4-methylthiazol-5-yl)benzyl)carbamoyl)pyrrolidin-1-yl)-3,3-dimethyl-1-oxobutan-2-yl)-3,9,12,18-tetraoxaicosanediamide
Purity: ≥98%
Cereblon Degrader (PROTAC®)

ARCC 4
Catalog #: 7254
Citations (10)
Product Documents
Images (1)

Potent and selective androgen receptor Degrader (PROTAC®)

Chemical Name: (2S,4R)-1-((S)-2-(2-(4-((4'-(3-(4-Cyano-3-(trifluoromethyl)phenyl)-5,5-dimethyl-4-oxo-2-thioxoimidazolidin-1-yl)-[1,1'-biphenyl]-4-yl)oxy)butoxy)acetamido)-3,3-dimethylbutanoyl)-4-hydroxy-N-(4-(4-methylthiazol-5-yl)benzyl)pyrrolidine-2-carboxamide
Purity: ≥98%
Potent and selective androgen receptor PROTAC®

TBK1 PROTAC® 3i
Catalog #: 7259
Citations (3)
Product Documents
Images (1)

Potent TANK-binding kinase 1 (TBK1) PROTAC®

Chemical Name: (2S,4R)-1-((S)-18-(4-((5-Bromo-4-((3-(N-methylcyclobutanecarboxamido)propyl)amino)pyrimidin-2-yl)amino)phenoxy)-2-(tert-butyl)-4-oxo-6,10,15-trioxa-3-azaoctadecanoyl)-4-hydroxy-N-(4-(4-methylthiazol-5-yl)benzyl)pyrrolidine-2-carboxamide
Purity: ≥98%
Potent TANK-binding kinase 1 (TBK1) PROTAC®

JQAD1
Catalog #: 7682
Citations (3)
Product Documents
Images (1)

Potent and selective EP300 Degrader (PROTAC®)

Chemical Name: 12-((2-(2,6-dioxopiperidin-3-yl)-1,3-dioxoisoindolin-5-yl)amino)-N-((R)-3'-(2-((4-fluorobenzyl)((S)-1,1,1-trifluoropropan-2-yl)amino)-2-oxoethyl)-2',4'-dioxo-2,3-dihydrospiro[indene-1,5'-oxazolidin]-5-yl)dodecanamide
Purity: ≥98%
Potent and selective EP300 Degrader

BSJ-03-204
Catalog #: 6938
Citations (2)
Product Documents
Images (1)

Selective Cdk4/6 Degrader (PROTAC®

Chemical Name: N-[4-[4-[6-[(6-Acetyl-8-cyclopentyl-7,8-dihydro-5-methyl-7-oxopyrido[2,3-d]pyrimidin-2-yl)amino]-3-pyridinyl]-1-piperazinyl]butyl]-2-[[2-(2,6-dioxo-3-piperidinyl)-2,3-dihydro-1,3-dioxo-1H-isoindol-4-yl]oxy]acetamide
Purity: ≥98%
Selective Cdk4/6 Degrader (PROTAC®)
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